To estimate the effect of these associations in prospective population-based studies, we had a sufficient number of stroke cases for the analysis in only the cardioembolic subtype (n=376). We noted ORs similar to those identified in the overall case-control study for both PITX2 (1·26, 95% CI 1·05–1·52, in prospective studies and 1·36, 1·27–1·47, in case-control analysis) and ZFHX3 (1·23, 0·98–1·55, in prospective studies and 1·25, 1·15–1·35, in case-control analysis), although this similarity was significant only for PITX2 (appendix).
