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Chunk #61 — Figure 1

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Human iPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia.
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Functional and genomic assessment of schizophrenia-derived glial progenitor cellsThis schematic summarizes the steps involved in our analysis of glial progenitor cells derived from individuals with juvenile-onset schizophrenia, compared to GPCs derived from behaviorally-normal controls. The major output data include effects of SCZ origin on in vivo oligodendrocyte maturation and myelination (Figure 2); in vivo astrocyte differentiation and phenotype (Figure 3); in vitro differential gene expression (Figures 4 and 5); and behavioral phenotype of the human glial chimeric host animals (Figure 6).See also Figure S1 and Table S1.