during the first few days of access (Racz et al., 2003). However, an important methodological difference separating this study from the others is that the ethanol was available ad libitum for several weeks, and while the initial pattern of drinking for CB1 KOs was different from wt mice, the consumption of the two groups was no different beyond the first few days of drinking. Lastly, the reduction in drinking associated with CB1 inhibition and deletion is decreased in aged mice suggesting that the interaction between the EC system and ethanol may be particularly important for the onset of AUDs in adolescence and early adulthood (Wang et al., 2003).
