We recruited 6,148 individuals, about 62% of the population aged 14 to 102 years, from a cluster of four towns in the Lanusei Valley (3). Subjects are native-born, and at least 95% are known to have all grandparents born in the same province (3). Valid personality data was obtained from 5,669 subjects (43), of which 3,972 were genotyped. The sample was composed of 2,250 women and 1,722 men (43.3%). Age ranged from 14 to 94 (M = 42.8, SD = 17).