PLINK was the fastest of these methods, followed by IMPUTE v1, BEAGLE, IMPUTE v2, and fastPHASE. PLINK also required the least RAM, followed by fastPHASE, IMPUTE v2, IMPUTE v1, and BEAGLE. While BEAGLE was quite fast, it also required more than ten times as much RAM as any other method (at least 2.5 GB per 7.5 Mb region of the genome). BEAGLE includes an option to decrease memory usage, but this would come at the cost of increased running time.
