Chunk #62 — Methods — MAGMA primary and conditional analyses

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Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease.

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We also evaluated the effect of varying window sizes (for the SNPs to gene assignment step of MAGMA) on the schizophrenia cell type associations strength (−log10(P)). We observed strong Pearson correlations in cell type associations strength (−log10(P)) across the different window sizes tested (Figure S27). Our selected window size (35kb upstream to 10 kb downstream) had Pearson correlations ranging from 0.94 to 0.98 with the other window sizes, indicating that our results are robust to this parameter.