In addition to replicating the association between rs1229984 and alcohol behavior, two other SNP associations we observed have been reported in previous papers. A SNP in ADH7 on chromosome 4, rs284779, was associated with DSM-IV dependence in a paper by Edenberg et al. (Edenberg et al., 2006). We found this SNP predicted a 4% increase in max drinks (P = 0.05), but was not associated with DSM-IV symptom count.
