Chunk #10 — RESULTS — MTAG Framework

Source

Multi-trait analysis of genome-wide association summary statistics using MTAG.

Embedded

yes

Text

We denote the vector of GWAS estimates of SNP j’s effects on the traits by β^j. We assume that the GWAS estimates are unbiased, E(β^j|βj)=βj, and we denote the variance-covariance matrix of their estimation error by Var(β^j|βj)=∑j. The off-diagonal elements of ∑j are non-zero whenever the estimation errors are correlated.