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Chunk #14 — Methods — Genotyping and Association Analysis

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Family-based association analysis of alcohol dependence criteria and severity.
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yes

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Genotyping for 2,105 subjects in these 118 families was performed at the Genome Technology Access Center at Washington University School of Medicine in St. Louis using the Illumina Human OmniExpress array 12.VI (Illumina, San Diego, CA, USA). In addition, genotypes previously generated on the Illumina Human 1M-Duo BeadChip (Illumina, San Diego, CA, USA)by the Center for Inherited Disease Research were also included for 224 subjects from these families (Edenberg et al., 2010). For quality control purposes, 51 of the 2,105 subjects were genotyped on both arrays and available for analysis, prior to sample exclusions (n=7) due to Mendelian inconsistencies.