Chunk #27 — Results — DMR-Associated Genes in the Dlg4 Network Exhibit Differential mRNA Expression in the NAc Adult F1 Offspring from THC-Exposed Lines
Dlg4 network (Dlgap2, Kcna5, Begain, Grin2a, and Dlg4) showed significant differential expression between THC and VEH groups (P<0.05; Table 3). Of the three genes associated with top DMRs that were tested, Mta1 tended to have higher expression in THC animals, though this difference was not statistically significant (P=0.057; Table 3). These results indicate effects of parental germline THC exposure on the epigenetic state of gene loci related to synaptic plasticity and the glutamatergic pathway within the NAc of adult offspring.
