However, our approach may be controversial to some readers given the unconventional reliance on self-report of major depression. We would reframe the issue: we hypothesize that brief methods of assessing major depression are informative for the genetics of MDD. We present a body of results that are consistent with this hypothesis. Even if unconventional, our hypothesis is testable and falsifiable, and we invite and welcome empirical studies to further support or refute this hypothesis.
