A number of the genes in Figure 3 have been implicated in alcohol abuse, such as (a) Acta1 gene expression differences are found between iP and iNP rats (Kimpel et al., 2007); (b) Irf3 gene expression differences are found between iP and iNP rats (Kimpel et al., 2007); (c) Tceb3 gene expression is increased in the frontal cortex of cirrhotic alcoholics vs. controls (Liu et al., 2007); and (d) Tpm3 gene expression is decreased in the ACB of iP rats operantly self-administering ethanol (Rodd et al., 2008), with Tpm3 protein expression levels decreased in the amygdala of chronic ethanol-drinking iP rats, but increased in the ACB of iP rats given multiple scheduled-access sessions of ethanol per day as well (Bell et al., 2006a).
