We quantified the preservation (or lack thereof) of within-module topology between schizophrenia and control co-expression networks by calculating network-based preservation statistics. Our analysis is based on previously published methods implemented in the WGCNA package122, which requires a list of genes assigned to modules in a reference network, as well as adjacency matrices for both the reference and a test network. We thus ran two separate analyses, once with the controls-based network as the reference and the SCZ-derived network as the test, and vice versa
