(2002) conceptualized alcohol/drug addiction as a syndrome of impaired response inhibition and salience attribution, and summarized the involvement of the frontosubcortical circuits in addiction disorders.. Earlier studies done in our lab have consistently found that disinhibition and impulsivity were the key aspects in alcoholism (Cohen et al., 1997; Kamarajan et al., 2005a; Chen et al., 2007). Further, many researchers have considered impulsivity as the key vulnerability marker for substance-use disorders, especially alcoholism (see Verdejo-Garcia, 2008 for a review).
