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Chunk #40 — Results — Zfhx1b Is Required for Expression of Genetic Markers of Cortical Interneurons: cMaf, MafB and Cxcr7

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Dlx1&2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons.
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The gene expression array showed a ~3-fold reduction in the expression of cMaf (v-Maf), a leucine zipper-containing transcription factor (Table S1). cMaf, and its relative MafB, have been reported to be expressed in cortical interneurons (Cobos, 2006; Faux et al., 2009; Zhao et al., 2008). Likewise, the array identified reduced expression of CXCR7, whose expression and function are required during cortical interneuron migration (Sánchez-Alcañiz et al., 2011; Wang et al., 2011).