reported in the previous study using analogous methodology and a different data set (17). While there was a difference in the gender distribution between the ADHD cases and the population-based comparison sample (which was 48% male), there was no significant difference in the rate at which CNVs >100 kb were called in males compared with females in either case or comparison subjects (data not presented). When we restricted the analysis to CNVs >100 kb that spanned genes, we found a significantly greater burden of such CNVs in case subjects, which was strongest for duplications (Table 1). There was no evidence of a greater burden of non-gene-centric CNVs >100 kb (minimum p=0.11; data not presented). As over 90% of CNVs >500 kb spanned at least one gene, the gene-centric burden analysis was limited to CNVs >100 kb.
