Our endophenotypes represent broadly the domain of psychophysiological measures that have been used to inform our understanding of psychopathology. Some of the endophenotypes we studied tap basic processes, like orienting and habituation (electrodermal reactivity), autonomic and central nervous system arousal (electrodermal activity and resting state electroencephalogram [EEG] power), and eye blink startle. Others constitute more complex measures related to information processing and emotion, like oddball P3 amplitude, inhibitory control over a prepotent response in the antisaccade task, and affectively modulated startle. Although we do not argue that these measures provide a representative sampling of psychophysiological endophenotypes and we acknowledge that there may exist some endophenotypes that are genetically more informative, our results are more broadly applicable than they would be if our conclusions were dependent on results from a single selectively analyzed and reported variable.
