not always available. Moreover, the top-hits and best-guess approaches do not provide a means to select specific SNPs for follow-up, and this problem is not solved by meta-analysis. The approach of selecting the “lead” SNP at a locus, usually the SNP with the lowest p-value in the largest GWAS, is problematic because different GWAS can report different lead SNPs for the same locus because of differences in GWAS chips, genotyping quality, and data handling and analysis decisions. Thus, an approach is needed that facilitates systematic and replicable SNP selection from results of multiple GWAS.
