A rapidly growing field of research has advanced iPSC generation and allowed for their derivation from patient fibroblasts, keratinocytes,21 hair follicles,22 peripheral blood23 and likely most other cell types. The viral vectors originally used for delivering the reprogramming factors resulted in potentially deleterious genomic disruptions from viral integration. Integration-free viruses, plasmids, or small molecules are now routinely used to circumvent this issue.24 The generation of iPSCs remains a long and labor-intensive process plagued by variability between iPSC lines.25 A recent approach addressed some of these issues through the use of a fully automated robotic cell reprogramming system, which may allow the generation of large cohorts of patient-specific iPSCs.26
