et al., 2003). Residues homologous to those in the agonist binding loops at the β/α interface, are homologous in all members of the superfamily (Smith & Olsen, 1995; Sigel & Buhr, 1997; Corringer et al., 2000) and are also homologous to those of the respective “loops” A, B, C, of the α+ and D, E, and F of the γ- side forming the benzodiazepine binding site (Ernst et al., 2003).