Despite those results, most blood trans-eQTLs remain unexplained. To aid interpretation, we provide the results of per-phenotype gene ontology (GO) term enrichment analysis (Supplementary Note, Supplementary Table 12). In the Supplementary Note we also highlight additional examples of trans-eQTL variants associated with age of menarche34 (ZNF131 locus), lipid levels35 (FADS1/2 locus), IBD36 and SLE37 (IFIH1 locus), asthma38 (GSDMB locus), and height39 (CLOCK locus), and explore their potential biological mechanisms to show how trans-eQTL results can be used to generate hypotheses for further research (Supplementary Figure 11a–e).
