sequence of the Girk2 gene does not seem to influence the position of GIRK channels relative to the PSD. We did, however, detect significantly more Girk2c than Girk2a mRNA in the neuropil of CA1 in vivo, suggesting that RNA localization may play a role in setting the amount of GIRK2 isoforms in CA1 dendrites. Moreover, our RNA-Seq data suggest that the 3′ terminal exons of both isoforms may be extended in vivo, which could further regulate the targeting, translation, and turnover of these transcripts. Follow up studies looking at the significance of this extended transcription are needed.
