Alcohol challenges, however, are labor intensive, costly, and can only be implemented in healthy nonalcoholic subjects old enough to give informed consent (Ehlers et al., 2010; Schuckit et al., 1997a, b). To expand the number and diversity of individuals who can be evaluated for LR, our group developed the 12-item Self-Rating of the Effects of Alcohol (SRE) Questionnaire where subjects estimate the number of standard (10–12 gm of ethanol) drinks required to produce up to four effects they actually experienced at three different epochs of their lives (Schuckit et al., 1997a, b). The most often used SRE timeframes include estimations regarding the approximate first five times of consuming at least one full alcoholic drink (SRE5), and a SRE total value (SRET) that combines SRE5 with scores for the periods of heaviest drinking and recent three months. Compared to SRET, SRE5 depends solely on a person’s recollection of alcohol effects in the more distant past, and incorporating information from more recent alcohol experiences broadens the perspective the individual brings to the SRET evaluation. Higher SRE scores, indicating a lower LR per
