After QC filtering, 1285 cases and 4964 controls remained across the three European ancestry strata (EU, AJ, FC). Examination of quantile-quantile (Q-Q) plots and genomic control λ values of the individual subpopulation-specific analyses revealed no evidence of residual population stratification or systematic technical artifact (EU, λ=1.011; AJ, λ=0.993; FC, λ=0.971; Figure S8a-c). The Latin-American population isolate stratum (CVCR/ANT) showed a small inflation of the median test statistic (λ=1.044), indicative of some residual stratification between CVCR and ANT samples (Figure S6). However, no SNPs in this subpopulation-specific analysis had extreme p-values outside the expected null distribution (Figure S8d).
