Chunk #31 — Results — Dlx1/2-/- Constitutive and Zfhx1b Conditional Mutants Have Similar Changes in Gene Expression Related to Their Defects in Interneuron Migration
As Zfhx1b expression in the subpallial SVZ was greatly reduced in the Dlx1/2 mutants (Figures 5A-B’), and because interneuron migration to the cortex was greatly reduced in both the Dlx1/2-/- and Zfhx1b mutants, we hypothesized that loss of Zfhx1b may underlie some of the interneuron migration phenotype of the Dlx1/2-/- mutants. To evaluate this idea, we compared gene expression phenotypes of the Dlx1/2-/- constitutive null mutant with the Zfhx1b conditional (Nkx2.1-Cre) mutant at E15.5 (Figure 6).
