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Chunk #31 — DISCUSSION — Limitations and Strengths

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Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans.
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Here we confirm the ability to use electronic medical records (EMRs) linked to DNA to identify genotype-phenotype relationships. We identified several potentially novel associations across the genome for heart rate, PR interval, QT interval, and QRS duration. Additionally, we generalized several associations identified by GWAS in European and Asian -descent populations to African Americans. Most importantly, we extensively characterized European and Asian identified associations in African Americans by reporting population specific information such as allele frequency and linkage disequilibrium differences, which may be important in both research and clinic-based settings.