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Chunk #3 — INTRODUCTION

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A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy.
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We considered that pregnancy would be a situation characterized by considerable health and social pressure to stop smoking and proposed that the same genetic factor that leads individual smokers to consume more cigarettes could also influence smoking cessation in pregnancy. We aimed to test the hypothesis that the rs1051730 risk allele is associated with an increased likelihood of continued smoking in pregnancy.