Chunk #3 — INTRODUCTION

Source

Dermatan sulfate is involved in the tumorigenic properties of esophagus squamous cell carcinoma.

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The high expression of DS-epi1 in human SCC prompted us to analyze the amount, structure, and localization of DS in ESCCs. Further, using in vitro models of ESCC we aimed to elucidate whether IdoA in DS could have a functional role in critical aspects of tumor development.