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Chunk #22 — Results — Polygenic Scores

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Clinical, genomic, and neurophysiological correlates of lifetime suicide attempts among individuals with an alcohol use disorder.
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Figure 2 (Panel B) shows conditional PGS results from the multinomial logistic models comparing those with AUD who had attempted suicide (AUD+/SA+) and those with AUD who had not attempted suicide (AUD+/SA−), to those without an AUD diagnosis and who had not attempted suicide (AUD−/SA+ omitted for clarity, full results in Table S4). Relative to the AUD−/SA− group, the AUD (ORMETA = 1.16, 95% CI = 1.05, 1.28), DEP (ORMETA = 1.29, 95% CI = 1.16, 1.44), SMOK (ORMETA = 1.30, 95% CI = 1.17, 1.44), and SUI (ORMETA = 1.40, 95% CI = 1.22, 1.60) PGSs were all associated with increased odds of being in the AUD+/SA+ group. By contrast, only the AUD (ORMETA = 1.15, 95% CI = 1.08, 1.22) and SMOK (ORMETA = 1.30, 95% CI = 1.21, 1.39) PGSs were associated with increased odds of being in the AUD+/SA− group relative to the reference group (AUD−/SA−).