When investigating the relationship between global gamma/theta CFC and clinical presentation, we found that it was correlated with ACE (p-value = 0.030, rho = 0.527). Previous studies have found that gamma/theta CFC has been associated with dysfunction in the temporal lobe structures. However, since we calculated the global gamma/theta CFC score, it may be the reason for a significant correlation with ACE since it is a score for multiple cognitive domains (Mathuranath et al., 2000). Therefore, gamma/theta CFC may reflect decreased functional coupling between the temporal lobes and the rest of the brain. Total tau has previously been shown to be a marker progression from MCI to AD (Diniz et al., 2008) and associated with neurodegeneration regardless of the underlying condition (Jack and Holtzman, 2013) and may therefore be related to gamma/theta CFC. However, we did not find a significant correlation between total tau and gamma/theta CFC nor total ACE test score. This may be attributed to the low sample size or delays between neurodegeneration and subsequent changes in cognition. If gamma/theta CFC is to be considered as an early
