The described clinical problem indicates the necessity of determining the range of sarcosine or antidepressant doses used in concomitant treatment of schizophrenia. We suggest considering a flexible use of antidepressant dose, particularly when complicated by hypomania or irritability (also when these were present in the past). In our previous case study, we successfully proposed to adjust sarcosine daily dosing to between 1 and 2 g per day, particularly in combination with serotonergic substances.25 The symptoms hypothetically induced by sarcosine described in our earlier article had some features of hypomania but did not meet all of its criteria. Summarizing the results of the two works, we come to the conclusion that the normalization of mood can be achieved by adjusting the dose of sarcosine as well as antidepressants.
