Alternatively, the AA findings might be false positives. Due to sparser LD in AA relative to EA, the application of a uniform threshold of p < 5E-08 for attributing GWS in AAs may not be sufficiently stringent64,65. However, gene-based tests were also successful at identifying three significant genes. Thus, at least for the gene-based tests, even after correction for differences in LD, significant findings in the smaller AA sample were identified.
