Chunk #19 — 3. Pharmacogenetic Studies of Treatment for Alcohol Use Disorder in Individuals of Diverse Ancestries — 3.2 Individuals of East Asian Ancestry
Pharmacogenetic studies of treatment response for AUD in individuals of East Asian ancestry have largely focused on the A118G SNP and response to NTX. The allele frequencies of the A118G SNP vary as a function of ancestral background, such that individuals of East Asian ancestry are more likely to be G allele carriers relative to individuals of European ancestry, as about 40% of Koreans carry the G allele.19 These differences suggest that investigation of pharmacogenetic interactions of the A118G SNP with NTX’s effects is a necessary step in understanding how ancestral background influences treatment efficacy.
