Chunk #7 — MATERIALS AND METHODS — CNV detection

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An evidence-based approach to establish the functional and clinical significance of copy number variants in intellectual and developmental disabilities.

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Arrays were scanned using a GenePix Autoloader 4200AL, GenePix 4000B (Molecular Devices, Sunnyvale, CA) or Agilent scanner (Agilent Technologies, Santa Clara, CA). Results were analyzed using Feature Extraction and DNA Analytics software packages (Agilent Technologies, Santa Clara, CA). Data include only those imbalances that contained at least 4 consecutive probes with abnormal log2 ratios. Data are presented as minimum coordinates (sequence positions of the first and last probes within the CNV) in the NCBI36 genome assembly.