cancer, cardiovascular outcomes, and gastrointestinal disorders. Several studies have concluded that cannabis use during adolescence had a strong impact on risk for psychosis and incidence of schizophrenia as well as a causal association with poor school performance, lower educational attainment and early school dropouts, as reviewed in [166]. Many studies have also reported that cannabis use increased the risk for developing MDD and BD, as well as for maintaining high levels of anxiety over time, as reviewed in [128,166]. All these diverse harms that ensue from cannabis use have led different studies to conclude that cannabis use and misuse constitute a highly relevant public health challenge [166].
