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Chunk #41 — Materials and Methods — Selection of traits for analysis

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Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain.
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Traits were excluded from analysis if they were detected in less than 95% of samples for each tissue region. For each tissue region and trait type (CpG and mRNA) the 95% threshold was determined using total number of analyzable samples for this pairing of region and trait. A probe is considered detected for a sample if the reported Illumina Detection p-value was less than or equal to 0.01. Numbers of analyzable samples per trait (or assay) type and region are available in Table 1 overlap of detected probes among brain tissues is shown as Venn diagram in Figure S2.