Given the significant findings of KCNJ6 SNPs, we imputed additional SNPs in this region. Our imputed data show that the top three highly correlated SNPs (r2 > 0.99) in introns of KCNJ6 are associated with theta Fz at a genome-wide significance level (rs2835880, imputed, P = 2.80 × 10−10; rs2835872, genotyped, P = 4.70 × 10−10; rs10483038, imputed, P = 6.60 × 10−10). A synonymous SNP, rs702859 (imputed) in KCNJ6 that is highly correlated with the top three SNPs, rs2835880, rs2835872, and rs10483038 (r2 > 0.8) is associated with theta Fz at P-value 1.60 ×10−8 (Table S1). Figure 2 displays KCNJ6 in the chromosome 21q22 association with theta Fz for both genotyped and imputed SNPs.
