The genomewide significant chromosome 10 SNPs represent a single LD signal, and are located in a region that is primarily intergenic. However, based on GENCODEv19 (51) annotation, there are multiple genes within the regulatory domain spanning these SNPs. While 5 of these 12 genes are expressed in brain-derived tissues (Supplemental Figure S4), none of the genomewide significant SNPs served as eQTLs for expression of these genes in GTEx, which includes modestly sized samples for a variety of brain tissue, nor in the larger Common Mind Consortium data, which includes 279 dlPFC samples. We found no evidence in the literature for the role of the genes within the regulatory domain in the etiology of addiction-related or other behavioral phenotypes.
