The aim of this study was to identify candidate genes for addiction and anxiety but also candidate genes that might be implicated in the generation of the EEG itself. Transmembrane currents originating in parietal/occipital regions for alpha and the hippocampus and limbic system for theta, are responsible for the magnitude of the recorded field. The rhythm generator for alpha originates in the thalamus [27]–[29] and in the hippocampus for theta [1] although the thalamus can act as an independent pacemaker for both alpha and theta rhythms [27]. Cholinergic and GABAergic afferents contribute to hippocampal theta activity [1]. The beta rhythm is thought to be mediated by GABAA interneurons [30]. Therefore it seems likely that numerous genes, other than CRH-BP, may have an influence on the EEG.
