The CRHR1 gene contains at least 14 exons spanning 20 kb of genomic DNA, and CRHR1 isoforms originate from the same gene by alternative splicing (Sakai et al., 1998). The findings presented here are the first to identify a significant association of the P3 amplitude, a quantitative trait endophenotype, and alcohol dependence with multiple SNPs from the introns and untranslated exons of the CRHR1 gene.
