The Structured Interview Guide of the Hamilton Anxiety and Depression Scale (SIGH-AD) (55) is administered as it assists with establishing severity of symptoms. The SIGH–AD is a 31-item structured interview that combines the Hamilton Depression Scale (HAM-D, 17 items) and the Hamilton Anxiety Scale (HAM-A, 14 items). Values over 15 represent clinically significant levels of anxiety or depression, respectively.