controls) as well as subsets of UK Biobank (including UK BiLEVE, 647 cases and 9,900 controls), COPDGene (557 cases and 2,255 controls), ECLIPSE (278 cases and 1,458 controls), NETT/NAS (87 cases and 277 controls), GenKOLS (120 cases and 734 controls), BioMe (8 cases and 199 controls) and DiscovEHR (774 cases and 472 controls). Analyses of the effect of lung function variants on COPD susceptibility and on risk of COPD exacerbations in a Chinese ancestry population were undertaken using the China Kadoorie Biobank prospective cohort (CKB) within which data were available for 71 (single variant analyses) or 70 (risk score analyses) of the 95 variants (or proxies) for analyses of COPD susceptibility (7,116 COPD cases and 20,919 controls) and risk of COPD exacerbation (5,292 cases and 1,824 controls). Further details of all studies, including case and control definitions are in the Supplementary Note and Supplementary Table 20.
