more than 10% of SNPs failed genotyping, and individual SNPs were removed if more than 10% of samples failed. The average call rate for both PLCO and NHS samples was 99.8%. Combined genome-wide analyses were restricted to directly-genotyped SNPs with minor allele frequencies above 1% in each study (ca. 518,000 SNPs). Additional description of these studies is available in previous reports [51], [52].
