GPC5 (glypican 5) became the gene of interest due to the statistical strength of the linkage data in mice and the association data in humans. The BXD linkage yielded a LOD score of 3.9 (P ≈ 1.25E−05), slightly shy of the genome-wide significance value of 4.3 (P ≈ 5.0E−06). Similarly, the multiple test corrected significance value for association to BSA was q = 0.08 (nominal P = 7.54E−05) very close to the standard q = 0.05 threshold for significance. Taken together, these data implicate GPC5 as a candidate QTL that influences ethanol-induced ataxia.
