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Chunk #29 — Results — Dysplasia within neocortex and archicortex, hippocampus and cerebellum

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The neuropathology of autism: defects of neurogenesis and neuronal migration, and dysplastic changes.
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In the cerebellum of the 60-year-old autistic male, severe hypoplasia affected lobes 1–4 (Fig. 4e). The thickness of the molecular and granular layer was decreased by almost 50% in comparison to that of the non-affected areas (Fig. 4e, f). The number of Purkinje cells was significantly reduced in the hypoplastic area. Hypoplastic changes within the portion of cerebellar cortex were observed, together with a significantly reduced convolution of the dentate nucleus (Fig. 4g).