disease etiologies; (2) provide additional insights about the overall pathologic mechanisms underlying different mutations carriers for variants as in genes such as TREM2, APOE, APP, PSEN1, and PSEN2; (3) correct the effect that altered cell composition and genetic statuses have in addition to downstream transcriptomic analyses and lead to novel and informative results; and (4) help the analysis of highly informative frozen brains collected over the years.
