P2Y1 receptor is one of the most abundant P2Y receptor subtype in brain tissues with large expression on neurons of the cerebellum,237 cerebral cortex, and ischemia-sensitive regions of the hippocampus that is predominantly implicated in AD.239 P2Y1R is also expressed on oligodendrocytes and astrocytes in the brain and optic nerves.240,241 Human P2Y1R is activated by ADP (EC50 = 10 nM),220,221 and ADP activation of the receptor induces platelet activation making this receptor as an important antithrombotic drug target.242 Like P2X7 receptor, P2Y1 receptor also mediates activation of microglia after brain injuries and insult.243
