that the results were not unduly influenced by this, we reran the top hits from Table 2 in the younger half of the sample, as defined by a median split on the age variable (≤ 39 years). The magnitude of the P-values was not as significant, as would be expected with a reduction in sample size of ~50%; however, nearly all P-values were still on the order of 10−3 or lower, and, importantly, the top hits in C1QTNF7 were still significant at P < 10−7. Accordingly, we feel confident that the results are not driven by poor retrospective reports among older participants.
