Chunk #43 — METHODS — Post-hoc analyses of European ancestry GWAS results — Polygenic Risk Score Analyses in Yale-Penn — Yale-Penn.

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Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders.

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For the present analysis, only Yale-Penn 3 EUR subjects (N=1,986) were included. DSM-IV29 substance abuse and dependence diagnoses (combined as abuse or dependence to represent use disorder) based on SSADDA assessments were used to determine case and control status for alcohol use disorder (AUD), cannabis use disorder (CUD), cocaine use disorder (CoUD), tobacco dependence (TD), and opioid use disorder (OUD). Of the 1,986 EUR subjects, 42.4% met criteria for AUD (N=843), 25.9% met criteria for CUD (N=515), 25.3% met criteria for CoUD (N=503), 31% met criteria for TD (N=615), and 22.6% met criteria for OUD (N=448). The mean age of Yale-Penn 3 EUR subjects is 41.5 (SE=15.1) and 51.5% are female (N=1,023).