Mammalian microfibril-associated glycoprotein (MAGP) shows peptide homology to sca and interacts with the Notch signaling pathway via direct interactions with the Notch1 receptor, as well as the Jagged1, Jagged2, and Dll-1 Notch ligands6,7. This suggests potential conservation of sca – Notch interactions between flies and mammals. It would be intriguing to investigate whether MAGP mediates memory of reward in mammals as it does in flies.
